What is Enoxaparin Injection?
Anticoagulant drugs are essential in the medical sector for treating and preventing blood clots. Enoxaparin is one such drug that has grown and gained prominence. On behalf of this article you will be know what does Enoxaparin injection do, Enoxaparin brands, Enoxaparin generic, enoxaparin administration conditions,Enoxaparin buying conditions Enoxaparin mechanism of action, and Enoxaparin clinical trials associated.
Enoxaparin injection is usually available with a prescription, and its availability and regulations may vary from country to country. Additionally, there was a severe shortage of Enoxaparin sodium on the market due to the significant drop in pricing and the need for Upstream feed Heparin in 2022. You may contact with German pharmaceutical wholesaler to supply Enoxaparin. If you would like to long-term of buying online Enoxaparin; you must work with a reliable and verified German pharmaceutical wholesaler like CGN Pharma GmbH.
Enoxaparin is available almost in all EU countries like Germany (Enoxaparin Lovenox), France (Enoxaparin Clexane/Lovenox), United kingdom (Xaparin/ Inhixa), Italy and Spain. Keep in mind that the availability and regulations of medications can vary between countries due to factors such as local healthcare systems, regulatory frameworks, and licensing agreements. Therefore, it’s important to seek information from reliable local sources to ensure accurate and current information regarding the availability of Enoxaparin in a particular country.
Enoxaparin Usage in the MENA Region
Enoxaparin has gained significant recognition and utilization in the Middle East and North Africa (MENA) region for the management of thromboembolic disorders. Enoxaparin registration and enoxaparin documents for application in the MENA area depend on coordinated efforts by medical experts, government agencies, and pharmaceutical distributors. To guarantee its optimal application and improve patient care, it is imperative that ongoing physician education programs emphasize the significance of early diagnosis, adequate risk stratification, and prompt beginning of Enoxaparin treatment. German pharmaceutical wholesaler CGN Pharma are trying to serve the whole world and can supply Enoxaparin Injection to all over the World if buyers’ are verified and had GDP.
What is Enoxaparin Used for? – Enoxaparin Indications
- Deep Vein Thrombosis (DVT)
- Acute coronary syndromes
- Prophylaxis, treatment for pulmonary embolism
- Prophylaxis in a variety of scenarios
- Percutaneous coronary intervention (PCI)
- Periprocedural anticoagulation
Enoxaparin Contraindications
- Hypersensitivity
- Thrombocytopenia
- Severe Renal Impairment
- Epidural or Spinal Anesthesia
Enoxaparin Mechanism of Action
Enoxaparin is an indirect anticoagulant that binds to and amplifies antithrombin III (a serine protease inhibitor), forming a complex that permanently inactivates factor Xa. As a result, the process of producing fibrin, the protein in charge of blood clot stability, is also impeded. The mechanism of action of enoxaparin sets it apart from unfractionated heparin (UFH), a different widely used anticoagulant that inhibits both thrombin and Factor Xa.
What is difference between Heparin and Enoxaparin?
Although Enoxaparin is derived from Heparin but the primary difference between unfractionated Heparin and Enoxaparin is inhibition of Thrombin (factor-IIa) and factor-Xa.
Due to its higher bioavailability than heparin, enoxaparin is preferable. When the medication is administered subcutaneously, 90% of it is accessible. Also it can be used in intravenous form. [1]
Enoxaparin Clinical Trials
Over the years, numerous clinical trials have been conducted to evaluate the safety and efficacy of Enoxaparin. A meta analysis was done in 2018 on efficacy and safety of Enoxaparin. This analysis shows that Enoxaparin decrease rates of death and MI compared with other anticoagulants. [2] A new clinical study is done in 2019 which is double-blind randomized clinical trial on Enoxaparin prophylaxis efficacy. [3] Through extensive clinical trials, Enoxaparin has proven its efficacy and safety in various clinical settings, ranging from acute coronary syndromes to extended thromboprophylaxis. As ongoing research continues to explore its potential applications. These studies have strengthened its status as a widely accepted treatment choice, enhancing patient outcomes and lowering the incidence of thromboembolic disorders.
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References:
[1] E. A. Nutescu, A. Burnett, J. Fanikos, S. Spinler, and A. Wittkowsky, “Pharmacology of anticoagulants used in the treatment of venous thromboembolism,” J. Thromb. Thrombolysis, vol. 41, no. 1, pp. 15–31, Jan. 2016, doi: 10.1007/S11239-015-1314-3.
[2] W. Hai-Long, P. Xiao-Hua, and Y. Jian-Jun, “The Efficacy and Safety of Enoxaparin: A Meta-analysis,” Open Med., vol. 13, no. 1, p. 359, Jan. 2018, doi: 10.1515/MED-2018-0054.
[3] C. J. Pannucci, K. I. Fleming, C. Bertolaccini, A. M. Prazak, G. J. Stoddard, and A. Momeni, “Double-Blind Randomized Clinical Trial to Examine the Pharmacokinetic and Clinical Impacts of Fixed Dose versus Weight-based Enoxaparin Prophylaxis: A Methodologic Description of the FIxed or Variable Enoxaparin (FIVE) Trial,” Plast. Reconstr. Surg. Glob. Open, vol. 7, no. 4, Apr. 2019, doi: 10.1097/GOX.0000000000002185.
